Oral intakes of HA will be more effective as the molecule does not need
to penetrate the epidermis and will be absorbed and distributed to the
dermis via blood vessels.
HA in creams, lotions and serums will be unable to reach the dermis to
increase levels of HA in the skin. This is because HA has a large molecular
size and cannot penetrate the skin’s surfac
Orally administered HA will not be transformed and will act naturally to
increase the water content and the endogenous HA levels in all the skin
regions. Also, orally administered HA will avoid the office visits, the patient
inconvenience, the adverse events and the risk associated with injection
Injected HA needs to be chemically transformed (cross-linked) in order to
stay in the skin. This type of modification affects the natural biological
properties of the HA molecule (lower water-binding capacity, lower
production of extracellular matrix components) (1) and the injected HA will
act mechanically as an implant for a visible action only in the zone where it
has been injected.
Unlike collagen, HA is free from animal proteins and from possible
transmissible infectious agents (viruses and prions).
Finally, clinical studies showed that oral collagen was less effective than
oral HA to increase skin hydration and elasticity and to reduce wrinkles (2).
Collagen is only from animal origin whereas the HA in Rheoderm is from
non-animal origin. The purity of HA is higher than that of collagen and
collagen can produce allergic reactions whereas HA is completely
1.Laurent TC, Fraser JR. Hyaluronan. ‟FASEBJ.‟1992;6:2397–2404.
2.Simpson RM, Meran S, Thomas D, Stephens P, Bowen T, Steadman R, Phillips A. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. Am J Pathol. 2009;175(5):1915–1928.