WHAT IS RHEODERM ?
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RHEODERM is an orally administered product indicated to reduce the appearance of wrinkles and and restore the skin’s volume.
RHEODERM delivers a substantial quantity of hyaluronic acid inside the skin to increase skin hydration, elasticity and density.
RHEODERM also contains N-acetylcysteine which decreases oxidative stress and protects against cellular damage.
The overall result is a plumping effect and a healthy, younger looking skin.
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WHAT IS HYALURONIC ACID ?
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An essential molecule whose quantity decreases with age
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Hyaluronic acid (HA), a major component of the skin, is fundamental to retain water and maintain healthy skin tone, elasticity, and a smooth, youthful appearance (1).
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However, aging and extrinsic stimuli such as solar ultraviolet radiation, smoking, and air pollutants gradually reduces the amount of HA in the skin (2-5).
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The skin loses elasticity and firmness, becomes thinner and dry, and fine lines appear on its surface. Therefore, correcting this loss of HA is an essential component of an anti-aging strategy.
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A large molecule whose skin penetration is problematic
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As the molecular weight of HA is relatively high, its penetration in the skin is very problematic when topically applied, and HA-based creams, lotions and serums will only moisturize the superficial layers of the skin. On the contrary, when orally administered, 90% of the ingested HA is absorbed into the body and migrate into connective tissues, such as skin (6-8). HA will then increase water in the skin and stimulates collagen, HA and proteoglycan synthesis as demonstrated in several clinical studies (9-13).
As a result, HA will provide a durable and deep skin hydration with a plumping effect.
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WHAT IS N-ACETYLCYSTEINE ?
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N-acetylcysteine (NAC) is widely used as an antidote to acetaminophen overdose (14) and its administration has been reported to be beneficial in various medical fields such as dermatology, neurology, gastroenterology, nephrology and pulmonology. Its effectiveness is largely based on the free radical scavenging property of NAC.
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Supplementation with NAC significantly increases the levels of intracellular glutathione, the body’s major anti-oxidant (15). Glutathione is critically important for detoxifying an array of toxic substances and free radical–generating molecules. It thereby exerts a profound protective effect on cells. (16)
As this powerful antioxidant is frequently depleted in patients with stress and aging, RHEODERM will replenish glutathione levels and will thus decrease oxidative stress and cellular damage.
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THE WINNING COMBINATION
Hyaluronic acid
300 mg
N-acetylcysteine 600 mg
+
REFERENCES
1. Laurent TC, Fraser JR. Hyaluronan.‟FASEB J.‟1992;6:2397–2404. 2. Simpson RM, Meran S, Thomas D, Stephens P, Bowen T, Steadman R, Phillips A. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. Am J Pathol. 2009;175(5):1915–1928. 3. Holmes MW, Bayliss MT, Muir H. Hyaluronic acid in human articular cartilage. Agerelated changes in content and size Biochem J.‟1988;250(2):435–441. 4. Uitto J. Understanding premature skin aging. N Engl J Med. 1997;337(20):1463–1465. 5. M O Longas, C S Russell, X Y He. Evidence for structural changes in dermatan sulfate and hyaluronic acid with aging. Carbohydr Res. 1987 Jan 15;159(1):127-36. 6. Sato T. Hyaluronic acid. JSMUFF. 2005;2(6):323–328. (in Japanese) 7. Balogh L, Polyak A, Mathe D, Kiraly R, Thuroczy J, Terez M, Janoki G, Ting Y, Bucci LR, Schauss AG. Absorption, uptake and tissue affinity of high-molecular weight hyaluronan after oral administration in rats and dogs. J Agric Food Chem.‟2008;56(22):10582–10593. 8. Laznicek M., Laznickova A., Cozikova D., Velebny V. Preclinical pharmacokinetics of radiolabelled hyaluronan. Pharmacological Reports. 2012;64(2):428–437. doi: 10.1016/S1734-1140(12)70784-3. 9. Kajimoto O, Odanaka W, Sakamoto W, Yoshida K, Takahashi T. Clinical effect of hyaluronic acid diet for Dry skin - objective evaluation with microscopic skin surface analyzer - J New Rem & Clin. 2001;50(5):548–560. (in Japanese) 10. Sato T, Sakamoto W, Odanaka W, Yoshida K, Urushibata O. Clinical effects of hyaluronic acid diet for Dry and rough skin. Aesthe Derma. 2002;12:109–120. (in Japanese) 11. Sato T, Yoshida T, Kanemitsu T, Yoshida K, Hasegawa M, Urushibata O. Clinical effects of hyaluronic acid diet for moisture content of dry skin. Aesthe Derma. 2007;17:33–39. (in Japanese) 12. Yoshida T, Kanemitsu T, Narabe O, Tobita M. Improvement of dry skin by a food containing hyaluronic acids derived from microbial fermentation. J New Rem & Clin. 2009;58(8):143–155. (in Japanese) 13. Terashita T, Shirasaka N, Kusuda M, Wakayama S. Chemical composition of lowmolecular weight hyaluronic acid from (chicken) and maintaining the moisture effect of ski by a clinical test. Memoirs of the Faculty of Agri of Kinki University. 2011;44:1–8. (in Japanese) 14. Brok J, Buckley N, Gluud C. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database Syst Rev. 2006;(2):CD003328. 15. Dekhuijzen PN. Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. Eur Respir J. 2004;23(4):629-636. 16. Dickinson DA, Moellering DR, Iles KE, et al. Cytoprotection against oxidative stress and the regulation of glutathione synthesis. Biol Chem. 2003;384(4):527-537.