What is Hyaluronic Acid?

Hyaluronic acid (HA), a major component of the skin, is fundamental to retain water and maintain healthy skin tone, elasticity, and a smooth, youthful appearance (1). However, aging and extrinsic stimuli such as solar ultraviolet radiation, smoking, and air pollutants gradually reduces the amount of HA in the skin. (2-5) The skin loses elasticity and firmness, becomes thinner and dry, and fine lines appear on its surface. Therefore, correcting this loss of HA is an essential component of an anti-aging strategy. As the molecular weight of HA is relatively high, its penetration in the skin is very problematic when topically applied, and HA-based creams, lotions and serums will only moisturize the superficial layers of the skin. On the contrary, when orally administered, 90% of the ingested HA is absorbed into the body and migrate into connective tissues, such as skin (6-8). HA will then increase water in the skin and stimulates collagen, HA and proteoglycan synthesis as demonstrated in several clinical studies. (9-13) As the result, HA will provide a durable and deep skin hydration with a plumping effect.

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7.Balogh L, Polyak A, Mathe D, Kiraly R, Thuroczy J, Terez M, Janoki G, Ting Y, Bucci LR, Schauss AG. Absorption, uptake and tissue affinity of high-molecular weight hyaluronan after oral administration in rats and dogs. J Agric Food Chem. -2008;56(22):10582–10593.

8.Laznicek M., Laznickova A., Cozikova D., Velebny V. Preclinical pharmacokinetics of radiolabeled hyaluronan. Pharmacological Reports. 2012;64(2):428–437.doi: 10.1016/S1734-1140(12)70784-3.