What is Hyaluronic Acid?

Hyaluronic acid (HA), a major component of the skin, is fundamental to retain water and maintain healthy skin tone, elasticity, and a smooth, youthful appearance.(1) However, aging and extrinsic stimuli such as solar ultraviolet radiation, smoking, and air pollutants gradually reduces the amount of HA in the skin. (2-5) The skin loses elasticity and firmness, becomes thinner and dry, and fine lines appear on its surface. Therefore, correcting this loss of HA is an essential component of an anti-aging strategy.

As the molecular weight of HA is relatively high, its penetration in the skin is very problematic when topically applied, and HA-based creams, lotions and serums will only moisturize the superficial layers of the skin. On the contrary, when orally administered, 90% of the ingested HA is absorbed into the body and migrate into connective tissues, such as skin (6-8). HA will then increase water in the skin and stimulates collagen, HA and proteoglycan synthesis as demonstrated in several clinical studies. (9-13) As the result, HA will provide a durable and deep skin hydration with a plumping effect.